During the beyond alarming health crisis with the COVID-19 pandemic outbreak, breathing aids are an acute necessity where sanitization and the availability cannot be compromised. Physics-based simulations can elegantly enable crucial design decisions about shielding the further spread of the infection from patients receiving respiratory care mostly by mechanical ventilation. Imperatively, it is also required to design the ventilation system to deliver critical life support to the patient. Simulation-based optimization can accelerate the release of working models for patient welfare in this context. For instance, CFD simulations can evaluate the efficiency of ventilation delivered when a COVID-19 victim wears a mask to prevent aerosol transport due to coughing or sneezing provoking a severe infectious transmission. Accounting for the porosity, filtration efficiency of the mask, CFD can also provide resourceful insights on the sensitivity for particle entrapment. Along with such simulation-based therapeutic planning, this webinar also discusses the advantages of simulations to understand the heat and mass transfer in the incubators, deployed for critical neonate care. Parametric optimization for product design for nebulizers and MDIs will be presented as well through the session. Furthermore, the focus shall also be to demonstrate simulation compliance for the WHO standards in these applications.